A Transition‐Metal‐Free Synthesis of Multisubstituted Imidazoles

Abstract A novel and simple t ‐BuOLi/I 2 ‐mediated synthesis of 1,2,4‐trisubstituted imidazoles was developed without transition‐metal added. The transition‐metal‐free strategy tolerated a range of substrates and provided products in moderate to good yields with 100% regioselectivity.