材料科学
生物相容性
聚乙烯吡咯烷酮
纳米材料
纳米医学
荧光寿命成像显微镜
吸收(声学)
光热治疗
吲哚青绿
纳米技术
炎症性肠病
医学
体内
生物医学工程
荧光
纳米颗粒
病理
光学
疾病
生物技术
复合材料
物理
高分子化学
冶金
生物
作者
Jun Song,Taejun Yoon,Sun-Mi Lee,Chin Hee Mun,Dasol Kim,Jieun Han,Juwon Kim,Yonghee Bae,Taehee Kim,Young Nyun Park,Mann‐Ho Cho,Yong Bum Park,Keunje Yoo
标识
DOI:10.1002/adfm.202107433
摘要
Abstract Recently, 2D nanomaterials have received considerable attention in nanomedicine due to their intrinsic optical properties, biocompatibility, and therapeutic effect. Here, 2D germanium telluride (GeTe) nanosheets coated with polyvinylpyrrolidone (PVP) (GeTe‐PVP NSs) developed as theranostic agents are reported that can be used for multispectral optoacoustic tomography (MSOT) and fluorescence imaging and therapy of inflammatory bowel disease (IBD). GeTe‐PVP NSs, fabricated by simple sonication in ethanol and PVP, show broad optical absorption in visible and near‐infrared (NIR) ranges (400–1200 nm) and have intrinsic fluorescence properties. Thus, they provide deeper ex vivo and in vivo MSOT tissue images than gold nanorods or indocyanine green with strong optical absorption in the first NIR window (700–900 nm). In addition, when orally administered to IBD mice, GeTe‐PVP NSs exhibit therapeutic efficacy similar to or higher than sulfasalazine, with strong accumulation at inflammatory colon sites. This demonstrates that oral administration of GeTe‐PVP NSs may be used to treat inflammatory diseases in the gastrointestinal tract.
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