受体
免疫系统
生物
化学
生物物理学
生物化学
免疫学
作者
Pierre Jacob,Nak Hyun Kim,Fei-Hua Wu,Farid El Kasmi,Yuan Chi,William G. Walton,Oliver J. Furzer,Adam D. Lietzan,Sruthi Sunil,Korina Kempthorn,Matthew R. Redinbo,Zhen‐Ming Pei,Li Wan,Jeffery L. Dangl
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-06-17
卷期号:373 (6553): 420-425
被引量:352
标识
DOI:10.1126/science.abg7917
摘要
Calcium signaling for host cell death In response to microbial pathogens, some plants kill off their own cells to limit further spread of infection. The Toll/Interleukin-1 receptor/Resistance class of nucleotide-binding leucine-rich repeat receptors (known as TNLs) function in plants as immune receptors. These TNLs work together with a dedicated set of helper proteins. Jacob et al. reveal the structure of one of these helpers known as NRG1 (N REQUIREMENT GENE 1). The structure resembles a known animal cation channel. The authors demonstrate that helper NLRs directly control calcium ion influx to initiate host cell death, providing a mechanism for TNL outputs. Science , abg7917, this issue p. 420
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