医学
非那雄胺
米诺地尔
杜他星
二氢睾酮
男性型秃发
头皮
雄激素受体
内分泌学
毛发移植
内科学
雄激素
皮肤病科
药理学
前列腺癌
前列腺
激素
癌症
标识
DOI:10.1016/j.jaad.2021.11.013
摘要
Androgenetic alopecia (AGA) may affect up to 50% of adults. AGA is a genetic disorder with an excessive response to androgens. Patients with AGA have higher production of dihydrotestosterone and higher levels of 5 α-reductase and androgen receptors in the balding scalp. Excessive activation of the androgen receptors leads to follicular miniaturization through a progressively shorter anagen phase. Therapeutically, there are only 2 Food and Drug Administration-approved drugs for AGA: topical minoxidil and oral finasteride. Other therapies (low-dose oral minoxidil, dutasteride, spironolactone, platelet-rich plasma, red light, and 660-nm laser) have demonstrated some efficacy. Hair transplantation is effective for the right candidate. 1 Ho C.H. Sood T. Zito P.M. Androgenetic alopecia. in: StatPearls [Internet]. StatPearls Publishing, 2021https:/www.ncbi.nlm.nih.gov/books/NBK430924/Date accessed: November 7, 2021 Google Scholar
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