结直肠外科
医学
功能(生物学)
胃肠功能
普通外科
内科学
生物
腹部外科
细胞生物学
作者
Paul B.S. Lai,Zhiyan He
出处
期刊:PubMed
[National Institutes of Health]
日期:2025-06-25
卷期号:28 (6): 619-626
标识
DOI:10.3760/cma.j.cn441530-20250310-00093
摘要
Gastrointestinal dysfunction is a common and significant complication in colorectal surgical practice, which is associated with gut microbiota dysbiosis caused by various perioperative interventions. Currently, enhanced recovery after surgery (ERAS) protocols have been increasingly adopted in clinical practice, greatly accelerating the recovery of postoperative intestinal function. However, there are still no effective interventions in the ERAS protocols to target surgery-induced gut microbiota dysbiosis. Probiotics, as a key treatment method targeting the gut microbiota, can stimulate intestinal motility, inhibit the colonization of pathogenic bacteria, enhance intestinal barrier function, among other effects. Based on these effects of probiotics, they are expected to resolve the neglected gut microbiota dysbiosis, further accelerating the postoperative recovery of intestinal function after colorectal surgery. This article reviews the mechanisms and clinical progress in postoperative bowel functional recovery after colorectal surgery.
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