Chlorogenic acid promotes liver regeneration and repair after acetaminophen-induced liver injury via alleviating oxidative stress and enhancing fatty acid β-oxidation by activating Nrf2

activating Nrf2. Additionally, Nrf2 activation triggered the expression of PGC-1α, which further strengthened PPARα-mediated fatty acid β-oxidation, thereby supplying sufficient energy for CGA-promoted LR following ACM intoxication. These findings highlight CGA's hepatoprotective effects and suggest it as a promising dietary supplement for promoting LR following toxic injury.