Chlorogenic acid promotes liver regeneration and repair after acetaminophen-induced liver injury via alleviating oxidative stress and enhancing fatty acid β-oxidation by activating Nrf2

CGA promoted LR post-ACM intoxication by alleviating hepatic oxidative stress via activating Nrf2. Nrf2 activation also triggered PGC-1α expression, which strengthened PPARα-mediated fatty acid β-oxidation, thereby supplying sufficient energy for LR.