松弛素
内科学
内分泌学
血管平滑肌
一氧化氮
血管紧张素II
细胞内
化学
蛋白激酶A
污渍
肾素-血管紧张素系统
医学
激酶
平滑肌
激素
受体
血压
生物化学
基因
作者
Paola Failli,Silvia Nistri,Luca Mazzetti,Laura Chiappini,Danièle Bani
标识
DOI:10.1196/annals.1282.048
摘要
We tested the effects of relaxin on [Ca2+]i response to angiotensin II in smooth muscle (vSMC) and endothelial cells isolated from hypertensive (SHR) and normotensive (WKY) rats. Relaxin markedly reduced the [Ca2+]i response of vSMCs from WKY, but not from SHR rats. Western blots showed that cGMP-dependent protein kinase G was reduced in vSMCs from SHR as compared with WKY rats. Relaxin also blunted the [Ca2+]i response in endothelial cells from WKY, but not from SHR rats. However, in endothelial cells from SHR and WKY rats, protein kinase G was nearly unexpressed, thus accounting for an alternative pathway of the intracellular response to nitric oxide and relaxin. Hence, vSMCs and endothelial cells in SHR rats show a deficiency response to nitric oxide that may render them insensitive to relaxin.
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