Effect of ultra-fine powder technique on dissolution rates of andrographolide and dehydroandrographolide in Andrographis paniculata

To investigate the effects of ultra-fine powder technique on dissolution rates of the components in Andrographis paniculata.High performance liquid chromatography was employed to determine the concentration of andrographolide and dehydroandrographolide in common powdered or ultra-fine powdered Andrographis paniculata.The dissolution rates of andrographolide and dehydroandrographolide in ultra-fine powdered Andrographis paniculata were higher than those of the general powder.Ultra-fine powder technique promotes the dissolution rates of andrographolide and dehydroandrographolide.