Synthesis and Preliminary Application of Chloromethoxy Butane

A new chloromethylation reagent,chloromethoxy butane(CMB),was prepared with butanol,paraformaldehyde and dry hydrogen chloride as raw materials.The product was analysized by method of FTIR and 1HNMR.The effects of the volume of solvent,molar ratio of reactants,reaction temperature and reaction time on the yield have been studied.The optimal reaction conditions were 50 mL of 1,2-dichloroethane and 3∶2 of the molar ratio of n-butanol to paraformaldehyde for reaction at 0~5 ℃ for 7 h.Under these conditions,the yield of chloromethoxy butane(CMB) can reach 92%.The chlorine content of the chloromethylated crosslinking polystyrene microsphere(degree of crosslinking 10%) with CMB reaches 13% detected by Volhard method.