Four new iridoid glycosides from the roots of Rehmannia glutinosa

AbstractAbstractFour new iridoid glycosides (1–4), rehmaglutosides L–O, were isolated from the air-dried roots of Rehmannia glutinosa. Their structures were established from the spectroscopic data obtained and by chemical evidence. The known mellittoside (5) and ajugol (6) were also obtained in the current investigation, and the structure of mellittoside was unequivocally defined using X-ray diffraction data. Compounds 1–6 were tested for their cytotoxicity against five human tumor cell lines and proliferation effects on Lactobacillus Reuteri. Keywords: ScrophulariaceaeRehmannia glutinosairidoid glycoside Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis work was financially supported by CAMS Initiative for Innovative Medicine [2021-I2M- 1-027-4], [2021-I2M-1-028-1] and the State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College.