生物
免疫系统
促炎细胞因子
获得性免疫系统
两栖动物
抗菌剂
免疫
免疫学
计算生物学
炎症
微生物学
生态学
作者
Jie Shi,Jing Wu,Guizhu Feng,Hailong Yang,Lingli Mu
出处
期刊:Protein and Peptide Letters
[Bentham Science]
日期:2023-07-01
卷期号:30 (7): 562-573
被引量:2
标识
DOI:10.2174/0929866530666230525163307
摘要
Abstract: Due to the rapid evolution of bacterial drug resistance, anti-infective treatment has become a global problem. Therefore, there is an urgent need to develop alternative treatment strategies. Host defense peptides (HDPs) are important components of the natural immune system and are widely distributed in the animal and plant kingdoms. Amphibians, especially their skin, provide a rich source of natural HDPs encoded by genes. These HDPs exhibit not only broad-spectrum antimicrobial activity but also a wide range of immunoregulatory characteristics, including modulation of antiinflammatory and proinflammatory reactions, regulation of specific cellular functions, enhancement of immune chemotaxis, regulation of adaptive immunity, and promotion of wound healing. They also show potent therapeutic effects on infectious and inflammatory diseases caused by pathogenic microorganisms. Thus, in the current review, we summarize the extensive immunomodulatory functions of natural amphibian HDPs, as well as the challenges of clinical development and potential solutions, which have important implications for the development of new anti-infective drugs.
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