化学
转鼓
亚胺
酰胺
立体化学
卡宾
催化作用
氢键
水解
吲哚试验
肽键
芳基
组合化学
分子
酶
有机化学
亲核细胞
烷基
作者
B. S. Harish,Manyam Subbi Reddy,Surisetti Suresh
标识
DOI:10.1002/ajoc.202200672
摘要
The total syntheses of h5-HT2A receptor antagonist, FPTase inhibitor, FGIN-1-27 and its analog have been accomplished from readily accessible starting materials such as ortho-amino cinnamyl ester/amides and substituted benzaldehydes. The N-heterocyclic carbene (NHC) catalyzed reaction enabled the synthesis of versatile intermediates, 2-aryl indole-3-acetic acid derivatives. Further synthetic manipulations such as N-alkylation, ester hydrolysis, amide bond formation, and carbonyl reduction delivered the titled biologically potent molecules in very good overall yields.
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