癌症
肿瘤微环境
间质细胞
背景(考古学)
骨髓
肥胖
炎症
生物
免疫系统
医学
癌细胞
肿瘤进展
生物信息学
缺氧(环境)
癌症研究
免疫学
内科学
内分泌学
化学
古生物学
有机化学
氧气
作者
Feifei Cheng,Jin He,Jing Yang
标识
DOI:10.1016/j.trecan.2023.03.007
摘要
Obesity is increasing globally and has been closely linked to the initiation and progression of multiple human cancers. These relationships, to a large degree, are mediated through obesity-driven disruption of physiological homeostasis characterized by local and systemic endocrinologic, inflammatory, and metabolic changes. Bone marrow microenvironment (BMME), which evolves during obesity, has been implicated in multiple types of cancer. Growing evidence shows that physiological dysfunction of BMME with altered cellular composition, stromal and immune cell function, and energy metabolism, as well as inflammation and hypoxia, in the context of obesity contributes to cancer initiation and progression. Nonetheless, the mechanisms underlying the obesity-BMME-cancer axis remain elusive. In this review, we discuss the recent advances in understanding the evolution of BMME during obesity, its contributions to cancer initiation and progression, and the implications for cancer therapy.
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