Fandresena Arilala Sendrasoa, Tsiory Iarintsoa Razafimaharo, Samson Leophonte Ramily, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja Department of Dermatology, Faculty of Medicine, University of Antananarivo, Antananarivo, 101, MadagascarCorrespondence: Fandresena Arilala SendrasoaDepartment of Dermatology, Faculty of Medicine, University of Antananarivo, Antananarivo, 101, Madagascar, Email nasendrefa@yahoo.frAbstract: The treatment of parotid hemangiomas has posed a challenge. A male infant presented with large hemangioma of the right parotid gland diagnosed at the age of 3 months. Starting at the age of 4 months, he was treated with oral propranolol for 10 months, which led to a marked reduction in tumor size and strawberry hemangioma. Our case shows that propranolol is effective and safe in treating large parotid infantile hemangioma.Keywords: large parotid hemangioma, propranolol, infantile