磺胺吡啶
Wnt信号通路
溃疡性结肠炎
信号转导
结肠炎
连环素
医学
病态的
内科学
胃肠病学
药理学
内分泌学
化学
生物化学
疾病
作者
Dong Ln,M Wang,Jingliang Guo,Wang Jp
出处
期刊:PubMed
日期:2019-07-01
卷期号:23 (14): 6371-6378
被引量:1
标识
DOI:10.26355/eurrev_201907_18461
摘要
To investigate the influences of probiotics combined with sulfasalazine (SASP) on the expression of the Wnt/β-catenin signaling pathway in rats with ulcerative colitis (UC).A total of 60 clean level and healthy Sprague-Dawley (SD) rats were randomly divided into the normal group, model group, SASP group and combination therapy group, with 15 rats in each group. The rats in the normal group were given normal feeding, and those in the remaining three groups were subjected to the establishment of the UC model. During the modeling, the rats underwent daily gavage and were sacrificed after 4 weeks. Clinical symptoms and pathological changes in ulcer indexes and colon tissues were observed in each group. The expression levels of relative genes in the Wnt/β-catenin signaling pathway were detected by Polymerase Chain Reaction (PCR).Compared with those in the model group, the pathological sections of rats in the SASP group and combination therapy group showed significant improvement in the inflammatory response. The expression levels of relative genes in the Wnt/β-catenin signaling pathway were downregulated in rats of the SASP group and combination therapy group relative to those in the model group.SASP and probiotics alleviate UC by reducing inflammation by inhibiting the activation of the Wnt/β-catenin signaling pathway, thereby improving intestinal function and restoring the intestinal structure.
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