The Crohn's disease rarely affects duodenum. The symptoms are unspecific and its diagnostic process may be difficult. Patients with complications-stenoses and fistules, are indicated for surgical treatment. According to literature, there is no straightforward agreement on the surgical treatment strategy. In most cases, non-resection procedures are indicated. The authors describe a case of a patient suffering from the Crohn's disease of his duodenum and chronic pancreatitis, which was managed using a radical procedure--hemipancreatoduodenectomy.