Advances of expressing heterologous protein in Pichia pastoris

Several hundred heterologous proteins have been expressed in Pichia pastoris as the rapid progress of genic engineering. In this review, the advantages and the composings of Pichia pastoris expression system and the translated methods and the expressed characteristics of the expression system were summarized. The wide applications of producing heterologous protein in the system were expatiated. Effect factors of heterologous protein,s expression in the expression system and the strategies for optimizing the expression system were also summarized stressly.