Aim To study the influence of microwave technique on the amount of rutin diffused from sophora flower.Methods With some different powder radius of chinese medicinal material,diffused time,output power microwave orthogonal test was carried out.Choose the best diffusing test design.The amount of rutin in the sophora flower diffusion was determined by UV.Results Influence of microwave technique on the amount of rutin was superior to the general decocting method.Conclusion Application of microwave technique in the chinese medicinal material diffusion is a new method.The amount of rutin diffused from powder sophora flower is larger than its prepared herbal medicine.The result is coincidence with the traditional chinese medical theory.