医学
切除术
腺癌
采样(信号处理)
体细胞
活检
产量(工程)
种系突变
肿瘤科
放射科
内科学
突变
外科
癌症
遗传学
基因
生物
计算机科学
材料科学
冶金
滤波器(信号处理)
计算机视觉
作者
Sue Dong,Emil Agarunov,Matthew Fasullo,Kiyoon Kim,Lauren Khanna,Gregory Haber,Eileen M. Janec,Diane M. Simeone,Paul E. Oberstein,Tamas A. Gonda
标识
DOI:10.14309/ajg.0000000000002786
摘要
We sought to determine the yield of somatic mutational analysis from EUS-guided biopsies of pancreatic adenocarcinoma compared to that of surgical resection and to assess the impact of these results on oncologic treatment.We determined the yield of EUS sampling and surgical resection. We evaluated the potential impact of mutational analysis by identifying actionable mutations and its direct impact by reviewing actual treatment decisions.Yield of EUS sampling was 89.5%, comparable to the 95.8% yield of surgical resection. Over a quarter in the EUS cohort carried actionable mutations, and of these, over one in six had treatment impacted by mutational analysis.EUS sampling is nearly always adequate for somatic testing and may have substantial potential and real impact on treatment decisions.
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