Mobile Resistance Elements: Symbionts That Modify Insect Host Resistance

Mounting evidence indicates that symbionts play a beneficial role through secondary metabolic compounds and various chemical processes in host adaptation to adversity, particularly in herbivorous insects whose survival is severely threatened by insecticides or secondary metabolite stress. Despite extensive research on insect symbionts, the spread of these beneficial symbionts and the correlation with host phenotypes limit our ability to predict and manage the adaptive capabilities of insect populations in changing environments. In this review, we propose the concept of "Mobile Resistance Elements (MRE)" to describe the dynamic and adaptable nature of resistance-related symbionts that can be transmitted between insect hosts. These elements encompass both the symbionts themselves and the associated traits they confer to their hosts, such as enhanced resilience to environmental stressors, toxins, and pathogens. The mobility of these resistance traits, facilitated through various transmission modes─including vertical and horizontal pathways─allows susceptible insect populations to acquire beneficial symbionts and their associated resistance phenotypes. By weaving together the threads of how symbionts shape host adaptability and survival strategies, this concept underscores the potential for symbionts to act as agents of rapid adaptation, enabling pest populations to thrive in changing environments and presenting both challenges and opportunities for pest management strategies.