萜类
立体化学
糖苷
阿卡波糖
化学
绝对构型
立体中心
有机化学
酶
对映选择合成
催化作用
作者
Sujuan Wang,Min Yu,Hua Li,Guijie Zhang
标识
DOI:10.1021/acs.jnatprod.1c00947
摘要
Sixteen new (1-16) and three known (17-19) polyacylated ent-kaurane diterpenoid glycosides were isolated from the aerial parts of Inula hupehensis. The planar structures of 1-16 and their relative configurations were established on the basis of extensive spectroscopic analysis. The absolute configurations of all stereogenic centers for compounds 1 and 6 were determined by single-crystal X-ray diffraction experiments, and the absolute configurations of the other new compounds were assigned by chemical degradation and experimental ECD data. Antineuroinflammatory testing of all the isolates showed that compound 5 inhibited lipopolysaccharide-induced nitric oxide production in BV-2 microglial cells with an IC50 value of 15.6 μM. In an α-glucosidase inhibitory assay, compound 13 exhibited a strong inhibitory effect with an IC50 value of 32.8 μM, whereas the IC50 value of the positive control, acarbose, was 387.8 μM.
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