Alteration of Bone Metabolism Markers According to the Progression of Puberty

Purpose:The object of this study is to evaluate bone metabolism in healthy adolescents according to the progression of puberty. Methods:Forty boys(13.91.7 years) and 42 girls(12.11.6 years) were classified by Tanner stage (TS) and bone age. Serum levels of osteocalcin(OC) and bone specific alkaline phosphatase(BALP) were measured as bone formation markers. Serum level of C-terminal telopeptide of type I collagen (ICTP) and urinary N-terminal telopeptide of type I collagen(NTx) concentrations adjusted by creatinine concentrations were measured as bone resorption markers. Serum or urine levels of bone turnover markers in each pubertal development group and bone age group were analysed. Results:In boys, BALP and OC levels increased to peak levels significantly(P