寡核苷酸
环加成
化学
组合化学
立体化学
有机化学
生物化学
DNA
催化作用
作者
Anup M. Jawalekar,Nico J. Meeuwenoord,Jozef G. O. Cremers,Herman S. Overkleeft,Gijs A. van der Marel,and Floris P. J. T. Rutjes,Floris L. van Delft
摘要
A procedure is presented for copper(I)-catalyzed [3+2] cycloaddition of nucleosides and nucleotides in near-quantitative yield. Azido-alkyne cycloaddition was applied for the preparation of a range of adenosine dimers and derivatives with versatile functionality, as well as for the smooth condensation of two oligonucleotide strands. The described technology may find valuable application in the synthesis of oligonucleotide dimers and conjugates.
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