生物
登革热病毒
登革热
抗体依赖性增强
病毒学
传染性
病毒
病毒复制
U937电池
热休克蛋白
热休克蛋白70
病毒进入
热冲击
细胞生物学
细胞培养
基因
遗传学
作者
Salvador Chávez-Salinas,Ivonne Ceballos-Olvera,Jorge Reyes-del Valle,Fernando Medina,Rosa M. del Ángel
出处
期刊:Virus Research
[Elsevier]
日期:2008-12-01
卷期号:138 (1-2): 111-118
被引量:38
标识
DOI:10.1016/j.virusres.2008.08.012
摘要
The molecules involved in dengue virus entry into human cells are currently unknown. We have previously shown that two surface heat shock proteins (Hsps), Hsp90 and Hsp70 are part of a receptor complex in monocytic cells. In the present report, the effect of heat shock (HS) on dengue virus infection is analyzed. We have documented a more than twofold increase in dengue virus infectivity after HS treatment in monocytic cells U937; this effect correlates mainly with an increase in viral entry due to a major presence of both Hsps on the surface of monocytic cells, particularly in membrane microdomains. Interestingly, since heat shock treatment at 6 h post-infection also increased viral yields, it is likely that HS also modulates positively dengue virus replication.
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