氨基糖苷
自愈水凝胶
抗生素
化学
体内
庆大霉素
药理学
抗菌活性
药物输送
微生物学
药品
细菌
生物化学
医学
生物
生物技术
有机化学
遗传学
作者
Jingjing Hu,Yanchun Quan,Yuping Lai,Zheng Zhao,Zhiqi Hu,Xinyu Wang,Tianjiao Dai,Qiang Zhang,Yiyun Cheng
标识
DOI:10.1016/j.jconrel.2017.01.003
摘要
Aminoglycosides are a family of critically important antibiotics for the treatment of serious infections including multidrug-resistant pathogens. However, clinical use of aminoglycoside antibiotics is compromised by bacterial biofilm formation at subinhibitory concentrations or adverse side effects such as ototoxicity and nephrotoxicity at high antibiotic doses. Preparation of aminoglycoside formulation that allows on-demand drug delivery is a solution to this sticky issue. Here, we designed a new type of aminoglycoside hydrogels by cross-linking oxidized polysaccharides such as dextran, carboxymethyl cellulose, alginate, and chondroitin using aminoglycosides as cross-linkers. The hydrogel modulus, degradation rate and release kinetics can be precisely modulated by tailoring the aminoglycoside dose during gel formation. The aminoglycoside hydrogel showed fast gelation, self-healing and on-demand drug release behaviors, and high antibacterial activities in vitro and in vivo against both Gram-positive and Gram-negative bacteria. This study provides a facile and promising strategy to develop smart hydrogels for topical administration of aminoglycoside antibiotics.
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