癌症研究
过继性细胞移植
肿瘤浸润淋巴细胞
离体
免疫疗法
医学
肿瘤微环境
渗透(HVAC)
体内
癌症
免疫系统
免疫学
T细胞
病理
生物
肿瘤细胞
材料科学
内科学
生物技术
复合材料
作者
Vaishali Inamdar,Shuai Hao,Sirkka B. Stephan,Matthias T. Stephan
标识
DOI:10.1016/j.jconrel.2024.04.040
摘要
Adoptive cell therapy with tumor-infiltrating T cells (TILs) has generated exciting clinical trial results for the treatment of unresectable solid tumors. However, solid tumors remain difficult targets for adoptively transferred T cells, due in part to poor migration of TILs to the tumor, physical barriers to infiltration, and active suppression of TILs by the tumor. Furthermore, a highly skilled team is required to obtain tumor tissue, isolate and expand the TILs ex vivo, and reinfuse them into the patient, which drives up costs and limits patient access. Here, we describe a cell-free polymer implant designed to recruit, genetically reprogram and expand host T cells at tumor lesions in situ. Importantly, the scaffold can be fabricated on a large scale and is stable to lyophilization. Using a mouse breast cancer model, we show that the implants quickly and efficiently amass cancer-specific host lymphocytes at the tumor site in quantities sufficient to bring about long-term tumor regression. Given that surgical care is the mainstay of cancer treatment for many patients, this technology could be easily implemented in a clinical setting as an add-on to surgery for solid tumors. Furthermore, the approach could be broadened to recruit and genetically reprogram other therapeutically desirable host cells, such as macrophages, natural killer cells or dendritic cells, potentially boosting the antitumor effectiveness of the implant even more.
科研通智能强力驱动
Strongly Powered by AbleSci AI