化学
香豆素
卟啉
光动力疗法
烷基
单线态氧
荧光
光化学
光毒性
组合化学
有机化学
氧气
生物化学
体外
量子力学
物理
作者
Zejie Tian,Lei Shi,Zhenhua Liu,Hui Li,Lingyan Yang,Yunmei Liu
标识
DOI:10.1016/j.molstruc.2023.135826
摘要
Photodynamic therapy (PDT) is attractive in cancer treatment because of its non-invasive and low side effects. In this study, we synthesized 20 porphyrin–coumarin compounds via condensation reactions of porphyrins with coumarin derivatives. In the singlet oxygen (1O2) assay, DPBF fluorescence was quenched by 85% after 10 s of light irradiation; the fluorescence of DPBF almost disappeared at 30 s by light irradiation. This indicates that the porphyrin–coumarin compounds have excellent 1O2 generation efficiency. Moreover, porphyrin–coumarin compounds showed different inhibitory effects on A549 and HepG2 cells under light irradiation. Whereas in dark conditions, compounds with shorter alkyl chains showed antitumor activity, the extension of branched and alkyl chains decreased the activity of the compounds. Therefore, accessing coumarin derivatives with shorter alkyl chains to porphyrins achieves PDT and chemotherapy. Additionally, the insertion of metal Zn into porphyrins also enhances the PDT effect of the compounds.
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