物理
微通道
机械
分离(统计)
粒子(生态学)
流量(数学)
计算机模拟
颗粒流
领域(数学)
统计物理学
经典力学
统计
海洋学
数学
离散元法
纯数学
地质学
作者
Hongyuan Zou,Wenbo Han,Yuhang Zhong,Han Yue,Wei Li,C. Zhang,Hongpeng Zhang
摘要
This paper systematically investigated the microfluidic chip with inertial contraction and expansion channels based on numerical simulation methods. The influence of geometric shape changes on the particle separation effect was focused on. We varied microchannel structural parameters such as contraction channel length and width, expansion channel length and width, and the overall curvature of the microchannel. The results indicated that different geometric structures hold diverse effects on the particle separation and particle recovery rate. An appropriate shrinkage–expansion ratio can improve the particle separation effect. In the microchannel, we found that six expansion channels and seven contraction channels are the optimal microchannel structure, which are capable of achieving effective separation of three types of particles. The vortex structure in the expansion channel dramatically impacts the focusing width of particles and the focusing distance of particles, which may be considered as the internal mechanism to explain the trajectory of particles in the channel. Furthermore, the curvature of the microchannel has a great influence on the particle recovery rate and particle separation effect. As the degree of bending leaps, the particle recovery rate will first decrease and then increase. This study establishes a theoretical foundation for understanding the interaction between diversifications in the geometric structure of microfluidic chips with inertial contraction and expansion channel structures and particle separation efficiency.
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