车站3
STAT蛋白
免疫系统
转录因子
生物
斯达
脂质代谢
信号转导
生物信息学
免疫学
神经科学
计算生物学
医学
癌症研究
细胞生物学
遗传学
内分泌学
基因
作者
Wei Hu,Jianjun Lv,Mengzhen Han,Zhi Yang,Tian Li,Shuai Jiang,Yang Yang
标识
DOI:10.1016/j.plipres.2018.04.002
摘要
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that has recently attracted increased attention. Accumulating studies have demonstrated that STAT3 plays an important role in various diseases, such as cancer and ischemic injury. In light of the distinctive effects of STAT3 on the regulation of metabolism and immune responses, we present the elaborate network of STAT3 in obesity. In this review, we first introduce the general background of STAT3, including a discussion regarding the STAT family and the characterization and regulation of STAT3. Then, we describe the STAT3 signaling network and its pathophysiological roles in lipid and glucose metabolism and immune function. Finally, we highlight the research progress regarding STAT3 in obesity. The information presented here may be useful for the design of future studies and may highlight the potential of STAT3 as a future therapeutic target for obesity.
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