蘑菇体
求爱
生物
果蝇属(亚属)
黑腹果蝇
神经科学
功能(生物学)
染色质
神经系统
基因
细胞生物学
遗传学
动物
作者
Ying Sun,Zhuojie Li,Wei Li,Lei Xue
标识
DOI:10.1016/j.neulet.2021.136432
摘要
The Drosophila Bicra (CG11873) gene encodes the sole ortholog of mammalian GLTSCR1 and GLTSCR1L, which are components of a chromatin remodeling complex involved in neoplasia and metastasis of cancer cells. Bicra is highly expressed in Drosophila larval CNS and adult brain, yet its physiological functions in the nervous system remain elusive. Here we report that Bicra is expressed in both neurons and glia of adult brains, and is required for courtship learning and choice ability of male flies. The function of Bicra in the mushroom body, and in particular, Bicra expression in neurons but not glia, is responsible for the male courtship learning and choice performance. This study unravels a novel function of Bicra in cognition-related courtship behaviors in Drosophila, and may provide insight into the neuronal functions of its mammalian orthologs.
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