Spatial Multi-Omics in Neurodegenerative Diseases

Neurodegenerative diseases represent a significant global health burden, characterized by the progressive deterioration of neuronal dysfunction and complex molecular pathologies. Traditional omics approaches have provided valuable insights into the genetic, transcriptomic, and proteomic alterations involved; however, they often lack spatial resolution, obscuring the tissue-specific and cellular-contextual dynamics of disease progression. Spatial multi-omics technologies integrate spatial transcriptomics, proteomics, epigenomics, and metabolomics to enable high-resolution mapping of molecular features within intact tissues. This chapter explores recent advancements in spatial multi-omics technologies and also the role of spatial multi-omics involving metabolomics, epigenomics, and their application to neurodegenerative disease models, as well as the challenges and future directions in translating these insights into clinical impact.