生物
转录因子
染色质
小RNA
癌基因
基因表达调控
细胞生物学
原癌基因蛋白质c-myc
细胞周期
抄写(语言学)
功能(生物学)
癌症研究
基因
遗传学
语言学
哲学
作者
Rajiv Kumar Jha,Fedor Kouzine,David Levens
标识
DOI:10.3389/fcell.2023.1268275
摘要
MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, metabolism, differentiation, and apoptosis. MYC interacts with several cofactors, chromatin modifiers, and regulators to direct gene expression. MYC levels are tightly regulated, and deregulation of MYC has been associated with numerous diseases including cancer. Understanding the comprehensive biology of MYC under physiological conditions is an utmost necessity to demark biological functions of MYC from its pathological functions. Here we review the recent advances in biological mechanisms, functions, and regulation of MYC. We also emphasize the role of MYC as a global transcription amplifier.
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