Changes In the Course of Energy and Oxidative Processes of The Brain During Its Ischemia

Energy deficiency and oxidative stress are stages of the biochemical cascade in brain damage of ischemic origin. There is information in the literature about their changes in certain types of ischemia, but there are no data on the features and comparative characteristics in cerebral ischemia of varying severity. It was found that the most pronounced disturbances in the prooxidant-oxidant balance and energy metabolism were observed in total cerebral ischemia. Similar, however, less pronounced disorders were found in daily subtotal ischemia and in the subgroup of stepped subtotal ischemia with an interval between ligation of the common carotid arteries of 1 day. The least pronounced disorders were in the subgroup with an interval between ligation of the common carotid arteries 7 days The aim of the work is to assess the state of the energy and oxidative processes of the brain during its ischemia of varying severity.