Determination of anti-influenza virus neuraminidase activity of L20051117 and AMMS607

Objective:To determine the inhibitory effect of compounds L20051117 and AMMS607 on influenza virus neuraminidase at molecular level.Methods:The anti-influenza virus neuraminidase activity of L20051117 and AMMS607 was examined by the fluorimetric assay.Results:The inhibitory effect of L20051117 on influenza virus neuraminidase was higher than that of AMMS607,the inhibition of influenza A virus neuraminidase by L20051117 and AMMS607 was higher than that of influenza B virus neuraminidase.Conclusion:L20051117 is a potent inhibitor of the neuraminidase activity of both influenza A and B virus.Its in vitro activity is higher than AMMS607.