Institutions of higher learning shoulder the historical mission and responsibility of talent training, and scientific research and cultivation are the fundamental embodiment and basic follow of the new era of "establishing moralities and cultivating people". This article uses research methods of literature and logical analysis to systematically analyze the spirit of scientific research and cultivation in colleges and universities in the new era, and proposes to establish a firm awareness of cultivating people and fulfill responsibilities; strengthen value guidance and insist on positive indoctrination; create education the specific methods and measures to sublimate rational cognition by exerting edification effect and focusing on practical experience, hoping to provide useful reference and help.