化学
环氧化物水解酶2
萜类
阿比坦
单体
立体化学
加合物
二维核磁共振波谱
环氧化物
核磁共振波谱
氢键
分子
有机化学
酶
催化作用
聚合物
作者
Wen‐Yu Zhao,Cheng‐Peng Sun,Yibo Chang,Weiyi Wang,Jian-Kun Yan,Xia Lv,Chao Wang,Xiaochi Ma
摘要
Biseuphoids A (1) and B (2), two unprecedented ent-abietane-type diterpenoid dimers linked by monomeric blocks through C-17-C-12' and C-17-C-11', respectively, were isolated from Euphorbia fischeriana, along with their biogenesis related diterpenoid monomers, 17-hydroxyjolkinolide B (3), caudicifolin (4), and fischeriabietane C (5). Their structures were elucidated by extensive spectroscopy assisted by quantum chemical NMR and ECD calculations. The unusual dimeric skeletons are possibly derived from the adduct of diterpenoid monomers through Michael-like reactions. The novel dimers 1 and 2 exhibited inhibitory activities on soluble epoxide hydrolase (sEH) with IC50 values of 8.17 and 5.61 μM, respectively. Molecular dynamics studies illustrated that both 1 and 2 can occupy the catalytic pocket of sEH by forming stable hydrogen bonds with the key amino acid residues including Gln384, Asn378, Pro361, Ala365, Asn366, and Asn472.
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