淀粉样变性
脑脊液
动力学
淀粉样蛋白(真菌学)
中枢神经系统
化学
血浆
病理
内分泌学
生物化学
医学
物理
量子力学
作者
Vitaliy Ovod,Kara N. Ramsey,Kwasi G. Mawuenyega,Jim G. Bollinger,Terry J. Hicks,Theresa Schneider,Melissa Sullivan,Katrina L. Paumier,David M. Holtzman,John C. Morris,Tammie L.S. Benzinger,Anne M. Fagan,Bruce W. Patterson,Randall J. Bateman
标识
DOI:10.1016/j.jalz.2017.06.2266
摘要
Cerebrospinal fluid analysis and other measurements of amyloidosis, such as amyloid-binding positron emission tomography studies, are limited by cost and availability. There is a need for a more practical amyloid β (Aβ) biomarker for central nervous system amyloid deposition.We adapted our previously reported stable isotope labeling kinetics protocol to analyze the turnover kinetics and concentrations of Aβ38, Aβ40, and Aβ42 in human plasma.Aβ isoforms have a half-life of approximately 3 hours in plasma. Aβ38 demonstrated faster turnover kinetics compared with Aβ40 and Aβ42. Faster fractional turnover of Aβ42 relative to Aβ40 and lower Aβ42 and Aβ42/Aβ40 concentrations in amyloid-positive participants were observed.Blood plasma Aβ42 shows similar amyloid-associated alterations as we have previously reported in cerebrospinal fluid, suggesting a blood-brain transportation mechanism of Aβ. The stability and sensitivity of plasma Aβ measurements suggest this may be a useful screening test for central nervous system amyloidosis.
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