巨噬细胞
细胞因子
膜
纳米颗粒
受体
化学
细胞生物学
材料科学
生物物理学
生物
医学
纳米技术
免疫学
生物化学
体外
作者
Hongyu Jiang,Zongguang Tai,Huijun Pan,Zhen Cui,Rongrong Chai,Congcong Zhu,Jing Tian,Leilei Bao,Quangang Zhu,Zhongjian Chen
标识
DOI:10.1166/jbn.2022.3324
摘要
Cytokine release syndrome (CRS) is a severe complication of infectious diseases like Coronavirus disease 2019 (COVID-19) that cause serious damage to public health. Currently, supportive therapy is still the main therapeutic strategy exists for CRS treatment. Here, we show the potential of macrophage membrane-derived biomimetic nanoparticles for CRS treatment. By fusing macrophage membrane on the surface of the PLGA nano core, we constructed biomimetic nanoparticles that inherited the membrane receptors from the “parental” macrophages, enabling the neutralization of CRS-related cytokines. We compared three types of macrophage membranes to screen out more effective biomimetic nanoparticles for CRS treatment. Our results show that M0 macrophage membrane-derived biomimetic nanoparticles could neutralize pro-inflammatory cytokines involved in CRS to the greatest extent and reduce organ damage in a mouse model.
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