黑色素瘤
淋巴结
淋巴
网状细胞
分泌物
癌症研究
医学
病理
生物
免疫学
内科学
脾脏
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2022-05-03
卷期号:82 (9): 1692-1694
被引量:1
标识
DOI:10.1158/0008-5472.can-22-0940
摘要
Abstract Melanomas coopt tumor-draining lymph nodes to support metastatic potential and install immunosuppression. The specific mechanisms that mediate lymph node education, however, remain incompletely understood. In this issue, Rovera and colleagues describe the deactivation of contractile lymph node fibroblasts by dedifferentiated melanoma cells, leading to lymph node expansion and enhanced melanoma invasive potential. Fibroblastic reticular cell relaxation depended upon inhibition of constitutive JAK1/STAT3 and YAP/TAZ signaling, which was mediated in part by tumor secretion of the inflammatory cytokine, IL1. These data support an emerging hypothesis that intrinsic melanoma heterogeneity feeds forward to drive microenvironmental adaptations that mediate invasion and progression. See related article by Rovera et al., p. 1774
科研通智能强力驱动
Strongly Powered by AbleSci AI