Plasma Levels of Thrombomodulin in Patients with Atherothrombotic Cerebral Infarction and Cerebral Hemorrhage

Objective To elucidate relationship between plasma soluble thrombomodulin (sTM) and small vascular injury and atherothrombosis in patients with atherothrombotic cerebral infarction and cerebral hemorrhage. Methods Plasma sTM was detected by ELISA in 60 patients with cerebral infarction, 56 patients with cerebral hemorrhage and 64 healthy controls. Relationships between sTM and blood lipids/blood pressure were analyzed. Results Levels of triglyceride and systolic blood pressure in patients with cerebral infarction and cerebral hemorrhage were higher than those of the control group. Level of high density lipoprotein of cerebral infarction and cerebral hemorrhage was higher than that of the control group. Level of total cholesterol in cerebral infarction was higher than that of other two groups. Level of sTM in patients with cerebral hemorrhage was higher than that of the other two groups. Level of sTM in patients with cerebral infarction was higher than that of the control. Level of sTM was significantly positively correlated with that of total cholesterol, trigliceride and systolic blood pressure. Level of sTM was significantly negatively correlated with that of high density lipoprotein.Conclusion High plasma sTM in patients with cerebral infarction and cerebral hemorrhage indicates small vascular injury caused by atherothrombosis and higher blood pressure. sTM is an independent risk factor of cerebral stroke. 