神经科学
生物
视皮层
感觉系统
生物神经网络
连接蛋白
缝隙连接
细胞生物学
句号(音乐)
细胞内
物理
声学
作者
Jérôme Ribot,Rachel Breton,Charles‐Félix Calvo,Julien Moulard,Pascal Ezan,Jonathan Zapata,Kevin Samama,Matthieu Moreau,Alexis-Pierre Bemelmans,Valentin Sabatet,Florent Dingli,Damarys Loew,Chantal Milleret,Pierre Billuart,Glenn Dallérac,Nathalie Rouach
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-07-02
卷期号:373 (6550): 77-81
被引量:47
标识
DOI:10.1126/science.abf5273
摘要
How astrocytes close a critical period During the visual critical period, brain circuits are rewired to adjust to sensory input. Closure of the critical period stabilizes the circuits. Looking at development in the mouse visual cortex, Ribot et al. found that astrocytes increase their expression of the gap junction channel subunit connexin 30, which in turn inhibits expression of a matrix-degrading enzyme (see the Perspective by Kofuji and Araque). As the matrix stabilizes, inhibitory interneurons mature, and the unusual flexibility of the critical period comes to an end. Science , abf5273, this issue p. 77 ; see also abj6745, p. 29
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