癌症
癌症免疫疗法
癌症研究
西妥昔单抗
肿瘤微环境
作者
Patrick McKay Boland,Wen Wee Ma
出处
期刊:Cancers
[MDPI AG]
日期:2017-05-11
卷期号:9 (5): 50-
被引量:89
标识
DOI:10.3390/cancers9050050
摘要
The recent success of anti-PD1 drugs in metastatic colorectal cancer patients with mismatch repair deficiency generated overwhelming enthusiasm for immunotherapy in the disease. However, patients with mismatch repair deficient colorectal cancer represent only a small subset of the metastatic population. Current research focuses on advancing immunotherapy to earlier stages of the disease including adjuvant and first-line metastatic settings, and on inducing sensitivity to immune checkpoint inhibitor therapy through a combinatorial approach. Here, we review the contemporary understanding of the immune and molecular landscape in colorectal cancer and discuss ongoing clinical trials evaluating novel combination regimens based on immune checkpoint inhibitors.
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