万古霉素
壳聚糖
自愈水凝胶
金黄色葡萄球菌
药物输送
抗生素
化学
微生物学
药理学
医学
细菌
生物
生物化学
遗传学
有机化学
作者
Junjie Wang,Yang Yu,Lijie Huang,Lili Kong,Xing Wang,Jingru Shi,Yinghua Lü,Haibo Mu,Jinyou Duan
标识
DOI:10.1016/j.ijbiomac.2022.07.212
摘要
Vancomycin (Van) remains one of the first-line drugs for the treatment of wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA). However, the unsatisfactory bioavailability of vancomycin alone has greatly limited its potential health benefits. Here a responsive chitosan-based hydrogel was developed as the delivery system which not only would reduce this side effect but also increase efficacy of vancomycin. The hydrogel was prepared by grafting chitosan and cinnamaldehyde-based thioacetal (CTA) together with ginipin (G) as the crosslinker. Upon exposure to reactive oxygen species which were enriched in the bacterial wound, the hydrogel can locally degrade and sustainably release the loaded vancomycin near the lesion to compete with the troubling MRSA. Compared with vancomycin alone, the chitosan-based hydrogel loaded with vancomycin demonstrated accelerated acute wound healing. This achievement reveals that this multi-functional hydrogel may be a promising drug-delivery device for improving the efficacy of local antibiotic therapy.
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