Enhanced Sonodynamic Therapy via Au Nanoclusters Deposited on TiO2 Nanosheets

Au nanocluster modification effectively tunes the sonodynamic performance of TiO₂ nanosheets by modulating electron-hole separation and ROS production. Notably, varying the Au content enabled precise regulation of SDT efficacy, with TiO₂-Au_10.5 achieving optimal therapeutic outcomes. These findings highlight TiO₂-Au as a safe, potent, and composition-tunable sonosensitizer platform for precise and effective cancer therapy.