癌症
医学
骨癌
骨转移
骨痛
转移
机制(生物学)
癌症疼痛
病理
内科学
认识论
哲学
出处
期刊:PubMed
日期:2014-08-01
卷期号:24 (8): 1185-91
被引量:2
摘要
Bone pain is one of the most frequent complications of bone metastasis, leading to a marked reduction in the quality of life of patients. The mechanisms of bone cancer pain are highly complicated ; however, noxious stimuli produced by cancer tissues and cancer-induced nerve injury are considered to be the major causes. Recent studies also suggest the possible involvement of acidic microenvironments created by cancer tissues and osteoclasts in cancer-induced bone pain. Understanding the molecular events may lead to the design of novel mechanism-based approaches for the management of bone pain associated with cancer metastasis.
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