血管生成
伤口愈合
绒毛尿囊膜
血管内皮生长因子
体内
医学
疤痕
透明质酸钠
细胞因子
软组织
新生血管
纤维接头
病理
外科
药理学
免疫学
癌症研究
生物
血管内皮生长因子受体
生物技术
作者
Gianfranco Favia,Mariggio Ma,Federico Maiorano,A Cassano,Saverio Capodiferro,Doménico Ribatti
出处
期刊:PubMed
日期:2008-07-04
卷期号:22 (2): 109-16
被引量:14
摘要
In this study we investigated the property of a new medical substance, in the form of a gel compound containing four aminoacids (glycine, leucine, proline, lysine) and sodium hyaluronate (AMINOGAM), to accelerate the wound healing process of the soft oral tissues and to promote angiogenesis in vivo in the vascular proliferation in chick embryo chorioallantoic membrane (CAM) assay. Furthermore, we investigated the capacity of AMINOGAM to induce the expression of an angiogenic cytokine, namely vascular endothelial growth factor (VEGF) in human fibroblasts in vitro. Results showed that AMINOGAM promoted wound healing in post-surgical wounds (after teeth extraction, oral laser surgery with secondary healing without direct suture of the surgical wound, and after dental implant insertion). Stimulated angiogenesis in vivo in the CAM assay and the response was similar to that obtained with vascular endothelial growth factor, a well-known angiogenic cytokine, tested in the same assay, and confirmed by clinical outcomes, which showed reduction of the healing time of oral soft tissues after three different kinds of surgery and also the absence of post-operative infections.
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