荟萃分析
医学
出版偏见
内科学
优势比
胶质瘤
肿瘤科
置信区间
胃肠病学
多态性(计算机科学)
等位基因
生物信息学
基因
遗传学
生物
癌症研究
作者
Jie Zeng,Yueji Luo,Min Yu,Jianming Li,Zhenghai Liu
出处
期刊:Advances in Clinical and Experimental Medicine
[Wroclaw Medical University]
日期:2017-11-30
卷期号:26 (8): 1275-1281
被引量:2
摘要
Background. Gliomas are the most common primary brain tumor in adults. Many studies have revealed associations between the rs4295627 polymorphism in the coiled-coil domain containing 26 (CCDC26) gene and the risk of glioma. However, the conclusions are still unclear because some studies have reported inconsistent results.Objectives. The aim of the present meta-analysis was to determine the relationship and quantitatively evaluate the effect of the rs4295627 polymorphism on the risk of glioma.Material and Methods. Data was extracted from PubMed, EMBASE and Google Scholar, with the most recent search up to December, 2015. Odds ratios (OR) and their 95% CIs were used to evaluate the effect of CCDC26 rs4295627 polymorphisms on glioma. A test of heterogeneity and an assessment of publication bias were also performed.Results. A total of 11 studies (8292 cases and 12,419 controls) were selected for this meta-analysis. Significant associations were observed in all genetic analysis models (G vs T: OR = 1.26, 95% CI = 1.12–1.43; GG vs TT: OR = 1.72, 95% CI = 1.24–2.39; GT vs TT: OR = 1.33, 95% CI = 1.24–1.42; GG + GT vs TT: OR = 1.36, 95% CI = 1.20–1.53; GG vs GT + TT: OR = 1.65, 95% CI = 1.18–2.29, respectively).Conclusion. The results of the present study clearly show that the G allele of the rs4295627 polymorphism significantly increases the risk of glioma. Nevertheless, well-designed large-scale studies are needed to further evaluate the effect of the rs4295627 polymorphism on different types or degrees of glioma in different ethnic groups as well as to measure the combined effects on glioma risk.
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