Computerized detection of cyclic alternating patterns of sleep: A new paradigm, future scope and challenges

Background and objectives: Sleep quality is associated with wellness, and its assessment can help diagnose several disorders and diseases. Sleep analysis is commonly performed based on self-rating indices, sleep duration, environmental factors, physiologically and polysomnographic-derived parameters, and the occurrence of disorders. However, the correlation that has been observed between the subjective assessment and objective measurements of sleep quality is small. Recently, a few automated systems have been suugested to measure sleep quality to address this challenge. Sleep quality can be assessed by evaluating macrostructure-based sleep analysis via the examination of sleep cycles, namely Rapid Eye Movement (REM) and Non Rapid Eye Movement (NREM) with N1, N2, and N3 stages. However, macrostructure sleep analysis does not consider transitory phenomena like K-complexes and transient fluctuations, which are indispensable in diagnosing various sleep disorders. The CAP, part of the microstructure of sleep, may offer a more precise and relevant examination of sleep and can be considered one of the candidates to measure sleep quality and identify sleep disorders such as insomnia and apnea. CAP is characterized by very subtle changes in the brain’s electroencephalogram (EEG) signals that occur during the NREM stage of sleep. The variations among these patterns in healthy subjects and subjects with sleep disorders can be used to identify sleep disorders. Studying CAP is highly arduous for human experts; thus, developing automated systems for assessing CAP is gaining momentum. Developing new techniques for automated CAP detection installed in clinical setups is essential. This paper aims to analyze the algorithms and methods presented in the literature for the automatic assessment of CAP and the development of CAP-based sleep markers that may enhance sleep quality assessment, helping diagnose sleep disorders. Methods: This literature survey examined the automated assessment of CAP and related parameters. We have reviewed 34 research articles, including fourteen ML, nine DL, and ten based on some other techniques. Results: The review includes various algorithms, databases, features, classifiers, and classification performances and their comparisons, advantages, and limitations of automated systems for CAP assessment. Conclusion: A detailed description of state-of-the-art research findings on automated CAP assessment and associated challenges has been presented. Also, the research gaps have been identified based on our review. Further, future research directions are suggested for sleep quality assessment using CAP.