The relationship between iron homeostasis and prognosis in patients with heart failure: a retrospective study based on the MIMIC IV database

ARTICLE Iron homeostasis and HF prognosis: a MIMIC -IV database -based study 1 and studies have shown that during the onset of HF, myocardial cells can exhibit disruptions in iron regulation. 7,8Current research has indicated that in patients with symptomatic HF, the prevalence of iron deficiency is approximately 50%, and iron deficiency can independently predict mortality. 9,10Iron deficiency negatively impacts the quality of life and prognosis of HF patients.Many studies suggested INTROduCTION As average life expectancy increases, the incidence and prevalence of heart failure (HF) have steadily risen in recent years. 1-3Iron, a trace element, is indispensable for various fundamental biological processes in humans and pathogens, encompassing activities from DNA synthesis to adenosine triphosphate generation.