The Ying and Yang of the Reelin Signalling Pathway in Alzheimer's Disease Pathology

Reelin is an extracellular protein crucial for brain development. To study Reelin functions in the adult forebrain we generated a transgenic mouse model that overexpress Reelin under the control of the CaMKIIα promoter (pCaMKII-Reelin-OE; Tg1/Tg2)l. Studies on Tg1/Tg2 mice indicate that Reelin regulates adult neurogenesis and migration, as well as the structural and functional properties of synapses. These observations suggest that Reelin controls developmental processes that remain active in the adult brain.